The human drug transport proteins or in combination with metabolic enzymes can affect the pharmacokinetics and pharmacodynamics of drug-drug interactions.
The most extensively studied human transporters are P-glycoprotein (P-gp or ABCB1) and breast cancer resistance protein (BCRP or ABCG2). They are recognized for their ability to confer multidrug resistance to various types of tumor cells.
Humeltis models express SLC and ABC transporters
Drug transporters are expressed in our tissue models (HNS) at a physiological level (Normal lung) (Figure 1) making Humeltis’ tissues suitable to study transport activities (Figure 2).
Active CYP450 enzymes are present
Several phase I and phase II metabolic enzymes are present in the pulmonary epithelium including Cyp1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C, 2D6, 2E1, 2F1, 2J2, 2S1, 3A4, 3A5, 4, FMO; UGT, GST, Esterases, Peptidases, etc. Humeltis models express many of the above enzymes and their activity can be studied using commercially available, selected fluorescent substrates.